What are Different Types of Hypersplenism?

Hypersplenism refers to increased splenic function with peripheral cytopenias and a reactive bone marrow.

Types-

1. Primary hypersplenism.

2. Secondary hypersplenism.

1. Primary hypersplenism- In it underlying disease cannot be identified to account for the exaggerated splenic function.

· Majority of patients are females.

· Fever, frequent and recurring infections and oral ulcerations with neutropenia.

· Petechiae and ecchymoses with thrombocytopenia.

· Pallor.

· Bone marrow reveals panacellular hyperplasia.

2. Secondary hypersplenism- In it underlying disease is identified. It includes a number of diseases sharing the common feature of splenomegaly. The mechanism producing splenic enlargement are-

· Work hypertrophy from immune response. Work hypertrophy from red cell destruction, for example, spherocytosis.

· Venous congestion.

· Myeloproliferation.

· Infiltration.

· Neoplastic proliferation.

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