Idiopathic Thrombocytopenic Purpura

It is a hemorrhagic disorder characterized by subnormal platelet count in presence of bone marrow containing normal or increased megakaryocytes and in absence of any systemic disease.

Symptoms-

1. This disease is mostly seen in females.

2. Petechiae or purpuric patches or ecchymoses in the skin and mucous membranes.

3. There is also a tendency to spontaneous bleeding revealed by bleeding gum, epistaxis, gastrointestinal hemorrhage, haematuria, haemarthrosis and menorrhagia in women.

4. Incidence of central nervous system bleeding is only 2 to 4% and may be the cause of death.

5. Spleen is palpable in only 10% of cases.

Investigations-

1. Platelet count- in peripheral blood is generally reduced. Platelet survival time is also short.

2. Bleeding time- is prolonged.

3. Bone marrow examination- reveals megakaryocytes either normal or increased in number.

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