Symptoms-
1. This disease is mostly seen in females.
2. Petechiae or purpuric patches or ecchymoses in the skin and mucous membranes.
3. There is also a tendency to spontaneous bleeding revealed by bleeding gum, epistaxis, gastrointestinal hemorrhage, haematuria, haemarthrosis and menorrhagia in women.
4. Incidence of central nervous system bleeding is only 2 to 4% and may be the cause of death.
5. Spleen is palpable in only 10% of cases.
Investigations-
1. Platelet count- in peripheral blood is generally reduced. Platelet survival time is also short.
2. Bleeding time- is prolonged.
3. Bone marrow examination- reveals megakaryocytes either normal or increased in number.
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Causes and Symptoms of Aortic Insufficiency