The most common enzyme defect in congenital hyperplasia is 21-hydroxylase deficiency. This enzyme defect is inherited as autosomal recessive trait.
Symptoms-
1. Glucocorticoid deficiency.
2. Mineralocorticoid deficiency.
3. Androgen excess.
4. Cortisol insufficiency.
5. ACTH and androgen excess.
6. Amenorrhea.
7. Hypertension.
Investigations-
Plasma 170H progesterone.
Management-
1. Replace deficient corticosteroids.
2. Suppress ACTH.
Do you know about- Renal Abscess
Chronic Pyelonephritis